Matthew R Reynolds,1 Jonas Nilsson,2 Örjan Åkerborg,2 Mehul Jhaveri,3 Peter Lindgren2,41Beth Israel Deaconess Medical Center, VA Boston Healthcare System, Boston, MA, USA; 2OptumInsight, Stockholm, Sweden; 3sanofi-aventis Inc, Bridgewater, NJ, USA; 4Institute of Environmental Medicine, Karolinska Institute, Stockholm, SwedenBackg
Production of pure lines is an important step in biological studies and breeding of many crop plants.The major types of pure lines for biological studies and breeding include doubled Ear Cleaner haploid (DH) lines, recombinant inbred lines (RILs), and near isogenic lines (NILs).DH lines can be produced through microspore and megaspore culture follo
Abstract Low-coverage imputation is becoming ever more present in ancient DNA (aDNA) studies.Imputation pipelines commonly used for present-day genomes have been shown to yield accurate results when applied to ancient genomes.However, post-mortem damage (PMD), in the form of C-to-T substitutions at the reads termini, and contamination with DNA from
Immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome, a rare autosomal recessive disorder, manifests with hypoglobulinemia and chromosomal instability accompanied by DNA hypomethylation.Pathological variants in the DNMT3B, ZBTB24, CDCA7, or HELLS genes underlie its etiology.Activated lymphocytes from patients often display